Evaluation and Comparison of Plasma miRNA-31 in Oral Squamous Cell Carcinoma

Background/Purpose: Oral Squamous cell carcinoma is sixth most common cancer with considerable morbidity and mortality. The microRNAs (miRNAs) are set of short RNAs involved in regulating the expression protein coding genes. They up or down-regulated carcinogenesis oral cancer. miRNA-31 (miR-31) increased Objective: To evaluate compare plasma squamous control subjects. Materials Methods: Case study was carried out 25 cases subjects normal level blood evaluated by miRNA easy kit (quagen) miRNA-based qRT-PCR. fold change observed compared between OSCC controls. Results: significantly patients to controls (p<0.001). moderately differentiated, grade 4 showed significant increase control, well differentiated 3 Conclusion: Our results indicate that miR-31 may be used as an adjuvant biomarker detection patient.